Sildenafil Drug Handout

What is Sildenafil?

Sildenafil belongs to a group of medications that delay the breakdown of the enzyme phosphodiesterase 5. It increases substances in the body that induce vasodilation (relaxation of arteries/ veins) within certain regions of blood vessels, like those found in the lungs.

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Uses/Indications

Pulmonary Hypertension secondary to primary respiratory disease (chronic bronchitis, COPD, pulmonary fibrosis), chronic mitral valve disease or thromboembolic disease (blood clots).

Adverse Effects

Please contact CVCA should any of these symptoms be noted

Low risk for decreased appetite, vomiting or diarrhea
Low blood pressure resulting in lethargy and weakness
Skin flushing

Client Information

Can be given with or without food
Comes in tablet form, but can be reformulated into capsules and liquid suspensions
Commonly used with other cardiac and respiratory medications
Does not require any specific monitoring

Interactions with Other Drugs

Increased risk for low systemic blood pressure when used with other vasodilators (amlodipine, acepromazine, phenoxybenzamine, nitrates)
Ketoconazole, itraconazole, cimetidine, erythromycin, and clarithromycin may increase blood levels
Phenobarbital may decrease blood levels lowering efficacy
The doctors at CVCA have taken this into account, however, please feel free to contact CVCA regarding any concurrent medications your pet may be prescribed

Standard Dosage Forms

Sildenafil tablets 20mg, 25mg, 50mg, 100mg

Synonyms: Viagra, Revatio